This key can do big changes.
I thought it was a bug. Images scale and position were accidentally dumped and the layout looks like a mess. This happened to me already on two projects. I didn't know why it was happening. And one day it dawned on me.
I used Alt+1 on early versions of PureRef to Increase the maximum opacity to the maximum value. So, when I clicked this button the layout become a mess, but I didn't notice because I worked on a small area and expected other scenarios (increased opacity). So, this button can disrupt all layout. Realize the scale of this nightmare, when you have a big project and accidentally pressed this key o_O
Some pictures :D
https://imgur.com/9ypv5N0
https://imgur.com/hNXDxhl